EXPRESSION OF CYCLIN D1 IN VARYING GRADES OF ORAL SQUAMOUS CELL CARCINOMA: AN IMMUNOHISTOCHEMICAL STUDY

Objective: Cyclin D1 promotes cell cycle progression during G1 phase, a key event in G1-S transition. It is positive regulator of cycle. Overexpression may lead to disturbance normal control and tumor formation. The objective the study was evaluate expression cyclin varying grades oral squamous carcinoma (OSCC). Methods: Nine formalin-fixed paraffin embedded tissues were immunohistochemically analyzed for OSCC. Results: Expression more poorly differentiated OSCC than moderately well-differentiated Conclusion: Increased seen thus can be used as biomarker aggressiveness